The BCL11A Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to BCL11A, BCL11A-L, and BCL11A-S. This antibody recognizes Human, Mouse, and Rat antigen. The BCL11A Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene